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Pimobendan(Vetmedin)
Description of:Pimobendan (Vetmedin)
Pimobendan (Vetmedin) is a calcium sensitizer with positive inotropic and vasodilator effects. It is als...
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PF-2545920
Description of:PF-2545920
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM.
Theoretical analysi...
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GSK256066
Description of:GSK256066
GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equ...
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Cilomilast(SB-207499)
Description of:Cilomilast(SB-207499)
Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). ...
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TH-302
Description of:TH-302
TH-302 is a selectively targeting hypoxic regions of solid tumors hypoxia-activated prodrug.
Theoretical analysis:T...
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TAK-700 (Orteronel)
Description of:TAK-700 (Orteronel)
orteronel(TAK-700) is currently in phase III clinical trials for the treatment of castration-resistant prost...
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Avasimibe(CI-1011)
Description of:Avasimibe(CI-1011)
Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor.
T...
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Apixaban
Description of:Apixaban
Apixaban is a compound being investigated as an anticoagulant. Apixaban has similar affinity for human and rabbit facto...
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Rivaroxaban(Xarelto)
Description of:Rivaroxaban(Xarelto)
Rivaroxaban significantly reduced the primary efficacy end point, as compared with placebo, with respective...
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Neuronal Signaling
PDE
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